Live RTICC Club- Prof. Yosef Shaul

Prof. Yosef Shaul
Department of Molecular Genetics, Weizmann Institute of Science

"Proteasome Function and Distribution: From Ubiquitin-Independent Degradation and Phase Separation to Neuronal Visualization"

Proteasomal degradation is central to maintaining protein homeostasis, traditionally via the ubiquitin–proteasome system (UPS). We uncovered that the 20S proteasome can also degrade intrinsically disordered proteins independently of ubiquitin and ATP. Using CRISPR-based fluorescent tagging, we tracked the live dynamics of 20S and 19S complexes in cell lines, embryonic stem cells, and differentiated neurons. This talk will highlight the distinct behaviors of proteasome complexes under osmotic stress and in neuronal contexts.

The LIVE RTICC CLUB is a monthly seminar series hosted at the Rappaport Cancer Research Center, designed to push the boundaries of cancer research. This dynamic event presents world-renowned international and national academic experts who present and discuss groundbreaking discoveries in cancer-related topics.
Each seminar features top-tier scientists who specialize in diverse areas such as oncology, genomics, immunotherapy, molecular biology, and more. Researchers, clinicians, and students alike have the opportunity to engage with cutting-edge insights and pioneering techniques aimed at advancing cancer research and ultimately improving patient outcomes.