RTICC International Guest Seminar- Prof. Ronny Drapkin

Prof. Ronny Drapkin
Director, Gynecologic Cancer Research, Basser Center for BRCA, University of Pennsylvania
Director, Penn Ovarian Cancer Research Center, University of Pennsylvania

"Rewiring the Tumor Microenvironment: Neural Circuits in Ovarian Cancer"

Metastasis remains the primary cause of cancer-related mortality, yet the influence of nerve signaling within the tumor microenvironment on metastasis is poorly understood. Here, we uncover a critical role for TRPV1-expressing sensory nerves in driving metastatic progression in high-grade serous ovarian cancer (HGSOC). We show that HGSOC tumors actively recruit TRPV1+ nerves by secreting the factor SLPI. Once within the tumor, these nerves release the neuropeptide nociceptin, which binds its cognate receptor OPRL1 on cancer cells to promote tumor growth, survival, and dissemination. Genetic or pharmacologic disruption of TRPV1, nociceptin, or OPRL1 profoundly impairs metastasis and improves survival in multiple in vivo models. Patient datasets reveal that this signaling axis is associated with poor prognosis across several cancer types. These findings define a previously unrecognized neural circuit in cancer and identify the TRPV1–nociceptin–OPRL1 pathway as a potential therapeutic target for limiting metastasis.

The RTICC aspires to become a leading center, attracting top-tier researchers renowned both nationally and internationally for their contributions to cancer research in various fields.
A key objective is to foster collaborations and engage with leading scientists, all with the aim of advancing cancer treatment and improving patient outcomes. Therefore, we host the RTICC International Guest Seminar, which is delivered by acclaimed expert academic speakers.